TOR regulates the subcellular localization of Ime1, a transcriptional activator of meiotic development in budding yeast.
Identifieur interne : 001921 ( Main/Exploration ); précédent : 001920; suivant : 001922TOR regulates the subcellular localization of Ime1, a transcriptional activator of meiotic development in budding yeast.
Auteurs : Neus Colomina [Espagne] ; Yuhui Liu ; Martí Aldea ; Eloi GaríSource :
- Molecular and cellular biology [ 0270-7306 ] ; 2003.
Descripteurs français
- KwdFr :
- Activation de la transcription (MeSH), Antibiotiques antinéoplasiques (pharmacologie), Azote (composition chimique), Carbone (composition chimique), Composés d'ammonium quaternaire (pharmacologie), Cycline G (MeSH), Cyclines (métabolisme), Cytométrie en flux (MeSH), Cytoplasme (métabolisme), Division cellulaire (MeSH), Facteurs de transcription (biosynthèse), Facteurs de transcription (physiologie), Facteurs temps (MeSH), Glutamine (composition chimique), Glutamine (métabolisme), Microscopie de fluorescence (MeSH), Modèles biologiques (MeSH), Méiose (MeSH), Noyau de la cellule (métabolisme), Plasmides (métabolisme), Protéines de Saccharomyces cerevisiae (biosynthèse), Protéines de Saccharomyces cerevisiae (physiologie), Protéines nucléaires (biosynthèse), Protéines nucléaires (physiologie), Régions promotrices (génétique) (MeSH), Saccharomycetales (métabolisme), Sirolimus (pharmacologie), Technique de Northern (MeSH), Technique de Western (MeSH), Transduction du signal (MeSH).
- MESH :
- biosynthèse : Facteurs de transcription, Protéines de Saccharomyces cerevisiae, Protéines nucléaires.
- composition chimique : Azote, Carbone, Glutamine.
- métabolisme : Cyclines, Cytoplasme, Glutamine, Noyau de la cellule, Plasmides, Saccharomycetales.
- pharmacologie : Antibiotiques antinéoplasiques, Composés d'ammonium quaternaire, Sirolimus.
- physiologie : Facteurs de transcription, Protéines de Saccharomyces cerevisiae, Protéines nucléaires.
- Activation de la transcription, Cycline G, Cytométrie en flux, Division cellulaire, Facteurs temps, Microscopie de fluorescence, Modèles biologiques, Méiose, Régions promotrices (génétique), Technique de Northern, Technique de Western, Transduction du signal.
English descriptors
- KwdEn :
- Antibiotics, Antineoplastic (pharmacology), Blotting, Northern (MeSH), Blotting, Western (MeSH), Carbon (chemistry), Cell Division (MeSH), Cell Nucleus (metabolism), Cyclin G (MeSH), Cyclins (metabolism), Cytoplasm (metabolism), Flow Cytometry (MeSH), Glutamine (chemistry), Glutamine (metabolism), Meiosis (MeSH), Microscopy, Fluorescence (MeSH), Models, Biological (MeSH), Nitrogen (chemistry), Nuclear Proteins (biosynthesis), Nuclear Proteins (physiology), Plasmids (metabolism), Promoter Regions, Genetic (MeSH), Quaternary Ammonium Compounds (pharmacology), Saccharomyces cerevisiae Proteins (biosynthesis), Saccharomyces cerevisiae Proteins (physiology), Saccharomycetales (metabolism), Signal Transduction (MeSH), Sirolimus (pharmacology), Time Factors (MeSH), Transcription Factors (biosynthesis), Transcription Factors (physiology), Transcriptional Activation (MeSH).
- MESH :
- chemical , biosynthesis : Nuclear Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , chemistry : Carbon, Glutamine, Nitrogen.
- chemical , metabolism : Cyclins, Glutamine.
- chemical , pharmacology : Antibiotics, Antineoplastic, Quaternary Ammonium Compounds, Sirolimus.
- metabolism : Cell Nucleus, Cytoplasm, Plasmids, Saccharomycetales.
- chemical , physiology : Nuclear Proteins, Saccharomyces cerevisiae Proteins, Transcription Factors.
- Blotting, Northern, Blotting, Western, Cell Division, Cyclin G, Flow Cytometry, Meiosis, Microscopy, Fluorescence, Models, Biological, Promoter Regions, Genetic, Signal Transduction, Time Factors, Transcriptional Activation.
Abstract
The transcriptional activator Ime1 is a key regulator of meiosis and sporulation in budding yeast. Ime1 is controlled at different levels by nutrients and cell-type signals. Previously, we have proposed that G(1) cyclins would transmit nutritional signals to the Ime1 pathway by preventing the accumulation of Ime1 within the nucleus. We show here that nutritional signals regulate the subcellular localization of Ime1 through the TOR pathway. The inactivation of TOR with rapamycin promotes the nuclear accumulation and stabilization of Ime1, with consequent induction of early meiotic genes. On the contrary, the activation of TOR by glutamine induces the relocalization of Ime1 to the cytoplasm. Thus, TOR may sense optimal nitrogen- and carbon-limiting conditions to modulate Ime1 function. Besides TOR, ammonia induces an independent mechanism that prevents the accumulation of Ime1 in the nucleus. Both TOR and ammonia regulate Ime1 localization in the absence of Cdk1 activity and therefore use mechanisms different from those exerted by G(1) cyclins. Integration of independent mechanisms into a single early controlling step, such as the nuclear accumulation of Ime1, may help explain why yeast cells execute the meiotic program only when the appropriate internal and external conditions are met together.
DOI: 10.1128/mcb.23.20.7415-7424.2003
PubMed: 14517308
PubMed Central: PMC230322
Affiliations:
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Le document en format XML
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Western</term><term>Cell Division</term><term>Cyclin G</term><term>Flow Cytometry</term><term>Meiosis</term><term>Microscopy, Fluorescence</term><term>Models, Biological</term><term>Promoter Regions, Genetic</term><term>Signal Transduction</term><term>Time Factors</term><term>Transcriptional Activation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation de la transcription</term><term>Cycline G</term><term>Cytométrie en flux</term><term>Division cellulaire</term><term>Facteurs temps</term><term>Microscopie de fluorescence</term><term>Modèles biologiques</term><term>Méiose</term><term>Régions promotrices (génétique)</term><term>Technique de Northern</term><term>Technique de Western</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The transcriptional activator Ime1 is a key regulator of meiosis and sporulation in budding yeast. Ime1 is controlled at different levels by nutrients and cell-type signals. Previously, we have proposed that G(1) cyclins would transmit nutritional signals to the Ime1 pathway by preventing the accumulation of Ime1 within the nucleus. We show here that nutritional signals regulate the subcellular localization of Ime1 through the TOR pathway. The inactivation of TOR with rapamycin promotes the nuclear accumulation and stabilization of Ime1, with consequent induction of early meiotic genes. On the contrary, the activation of TOR by glutamine induces the relocalization of Ime1 to the cytoplasm. Thus, TOR may sense optimal nitrogen- and carbon-limiting conditions to modulate Ime1 function. Besides TOR, ammonia induces an independent mechanism that prevents the accumulation of Ime1 in the nucleus. Both TOR and ammonia regulate Ime1 localization in the absence of Cdk1 activity and therefore use mechanisms different from those exerted by G(1) cyclins. Integration of independent mechanisms into a single early controlling step, such as the nuclear accumulation of Ime1, may help explain why yeast cells execute the meiotic program only when the appropriate internal and external conditions are met together.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14517308</PMID><DateCompleted><Year>2003</Year><Month>11</Month><Day>25</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0270-7306</ISSN><JournalIssue CitedMedium="Print"><Volume>23</Volume><Issue>20</Issue><PubDate><Year>2003</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Molecular and cellular biology</Title><ISOAbbreviation>Mol Cell Biol</ISOAbbreviation></Journal><ArticleTitle>TOR regulates the subcellular localization of Ime1, a transcriptional activator of meiotic development in budding yeast.</ArticleTitle><Pagination><MedlinePgn>7415-24</MedlinePgn></Pagination><Abstract><AbstractText>The transcriptional activator Ime1 is a key regulator of meiosis and sporulation in budding yeast. Ime1 is controlled at different levels by nutrients and cell-type signals. Previously, we have proposed that G(1) cyclins would transmit nutritional signals to the Ime1 pathway by preventing the accumulation of Ime1 within the nucleus. We show here that nutritional signals regulate the subcellular localization of Ime1 through the TOR pathway. The inactivation of TOR with rapamycin promotes the nuclear accumulation and stabilization of Ime1, with consequent induction of early meiotic genes. On the contrary, the activation of TOR by glutamine induces the relocalization of Ime1 to the cytoplasm. Thus, TOR may sense optimal nitrogen- and carbon-limiting conditions to modulate Ime1 function. Besides TOR, ammonia induces an independent mechanism that prevents the accumulation of Ime1 in the nucleus. Both TOR and ammonia regulate Ime1 localization in the absence of Cdk1 activity and therefore use mechanisms different from those exerted by G(1) cyclins. Integration of independent mechanisms into a single early controlling step, such as the nuclear accumulation of Ime1, may help explain why yeast cells execute the meiotic program only when the appropriate internal and external conditions are met together.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Colomina</LastName><ForeName>Neus</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalunya, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yuhui</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Aldea</LastName><ForeName>Martí</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Garí</LastName><ForeName>Eloi</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Cell Biol</MedlineTA><NlmUniqueID>8109087</NlmUniqueID><ISSNLinking>0270-7306</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000903">Antibiotics, Antineoplastic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D056746">Cyclin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016213">Cyclins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C080326">IME1 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009687">Nuclear Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000644">Quaternary Ammonium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0RH81L854J</RegistryNumber><NameOfSubstance UI="D005973">Glutamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-44-0</RegistryNumber><NameOfSubstance UI="D002244">Carbon</NameOfSubstance></Chemical><Chemical><RegistryNumber>N762921K75</RegistryNumber><NameOfSubstance UI="D009584">Nitrogen</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000903" MajorTopicYN="N">Antibiotics, Antineoplastic</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015152" MajorTopicYN="N">Blotting, Northern</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002244" MajorTopicYN="N">Carbon</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002455" MajorTopicYN="N">Cell Division</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002467" MajorTopicYN="N">Cell Nucleus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056746" MajorTopicYN="N">Cyclin G</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016213" MajorTopicYN="N">Cyclins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003593" MajorTopicYN="N">Cytoplasm</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005434" MajorTopicYN="N">Flow Cytometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005973" MajorTopicYN="N">Glutamine</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008540" MajorTopicYN="Y">Meiosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008856" MajorTopicYN="N">Microscopy, Fluorescence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="N">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009584" MajorTopicYN="N">Nitrogen</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009687" MajorTopicYN="N">Nuclear Proteins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010957" MajorTopicYN="N">Plasmids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011401" MajorTopicYN="N">Promoter Regions, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000644" MajorTopicYN="N">Quaternary Ammonium Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName 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